Mackenzie decides to change the direction of her administration - from reaction to action - and appoints Rod as Strategic Planning Adviser, much to the disgust of Chief of Staff Jim Gardner. Meanwhile, Vince's drug test reveals that he's HIV positive and Templeton plots to use this to his advantage. Mac is presented with scandalous information about Templeton's past and has to decide how to use the information. Later, Horace almost gets into a fight with Rebecca's boyfriend when he learns about the rumor he's spreading.
Mackenzie Allen, the 45-year old Independent Vice President, is about to enter a world in which no woman has ever stepped foot in before. While in attendance at a ceremony with her husband, Chief of Staff Rod Calloway, Mackenzie is given the startling news that President Bridges needs emergency brain surgery to treat a brain tumor. Mackenzie is given an additional shock when she is also informed that in the event the President doesn't make it through surgery, the party doesn't want her succeed him.
However, despite sexist insults from both the dying President and Speaker of the House Nathan Templeton, Mackenzie decides to fulfill her duty as Presidential successor and take her rightful place as Commander in Chief of the United States of America.