Garrett and his unit travel to Thailand when three American volunteers go missing during a trek to Bangkok. Once there, former colleague Clara Seger, a cultural anthropologist, helps them rush to gather evidence leading to the UnSub before a storm threatens to wash it away,.

When an American man attending a festival in Mumbai wakes up missing a kidney and his friend gone, the International Response Team's investigation leads them to suspect the UnSub is more than just trading organs on the Black Market.

The team make their way to Cairo after a former American serviceman ishuged in a gas attack and his friend disappears.

The team travels to Japan to assist local law enforcement in investigating homicides made to look like sleepings. Meanwhile, Mae encourages Clara to get out and enjoy herself.

The International Response Team make their way to Paris to look for an unsub who is targeting Americans who are living there.

Thinking that a honeymoon couple could have been abducted, the team make their way to Belize to investigate the disappearance.

The International Response Team travels to Morocco when a retired couple from Idaho is kidnapped while visiting the country on a cruise.

When a woman vacationing in Mexico with her family is the victim of foul play, the International Response Team investigates her husband as the prime suspect when he flees.

When an American girl leaves home to meet her boyfriend in Turkey, the International Response Team suspects she's in trouble after being tricked by someone posing as her boyfriend.

When an American college student working in Johannesburg ishuged and his brother goes missing, the International Response Team suspects a gang could be behind both. Jack works the case with Lieutenant Ananda Doshi, a profiler he's worked with before who has an unorthodox style of investigation.

When American victims are found in different locations throughout Cuba, the International Response Team heads to the island nation to search for possible spree huggers.

The IRT heads to Pamplona, Spain during the running of the bulls. The ears of a missing American tourist are found and the team speculates that the crime is politically motivated.

When the daughter of an American family visiting Haiti to adopt a child is kidnapped, the International Response Team travels to the island nation to try to find her. Also, Jack and his wife, Karen, prepare to send their daughter to college.