On their first day at Lawndale High, Daria and Quinn have to take a mandatory psychological exam, where perky, popular Quinn passes with flying colors, while sarcastic loner Daria is forced to enroll in a self-esteem course, where she meets the equally sarcastic Jane. Meanwhile, Quinn goes to great lengths to prevent people from knowing she's related to Daria, since she thinks that it will ruin her popularity.
The people of Lawndale just don't get Daria Morgendorffer. She's cool with that. See, Daria was born alienated, and now she's just trying to make it through high school with as little human contact as possible. Popularity, friends, activities... whatever. Daria lacks enthusiasm, but she makes up for it with sarcasm. Daria is the spin-off of MTV's most sucessful cartoon, Beavis and Butt-Head.