Holly J. starts to look for a kidney donor within her family, and when she finds out no one has the same blood type, she starts to suspect she was adopted, which are proven true. Adam is attracted to Katie, and thinks she may be reciprocating this feeling, but when Marisol says otherwise, he worries about his female appearance. Imogen wants to play the role of Clare in the school play, so she begins shadowing her.
Like its predecessors, Degrassi follows a group of students attending Degrassi Community School who face challenges common to teen life, such as self image, peer pressure, child abuse, sexual identity, gang violence, self-injury, school shootings, teenage pregnancy and drug abuse.
Degrassi (previously titled The Next Generation) is the fourth fictional series in the Degrassi franchise, following The Kids of Degrassi Street, Degrassi Junior High, and Degrassi High.