It's spring break and Manny, along with Emma, Liberty, and Ash head off to Smithdale University, where Manny plans on auditioning for a college theater program. Jay, upset that Manny didn't invite him along for the ride, decides to go with Spinner and Jimmy.
Like its predecessors, Degrassi follows a group of students attending Degrassi Community School who face challenges common to teen life, such as self image, peer pressure, child abuse, sexual identity, gang violence, self-injury, school shootings, teenage pregnancy and drug abuse.
Degrassi (previously titled The Next Generation) is the fourth fictional series in the Degrassi franchise, following The Kids of Degrassi Street, Degrassi Junior High, and Degrassi High.