Will Ferrell and Seth Rogen star in this episode about how teenage writer Mary Shelley created her legendary novel, "Frankenstein".

John Muir convinces Teddy Roosevelt to preserve Yosemite, journalist Marjory Stoneman Douglas fights to protect the Everglades, and Native American activists occupy Alcatraz.

Moses Fleetwood Walker faces racism in the 19th-century MLB; the Chicago White Sox are accused of intentionally losing the 1919 World Series; the Callaghan sisters inspire the film "A League of Their Own".

Bessie Coleman is America's first black woman pilot; the students of the Little Rock Nine integrate a high school following the Brown v. Board of Education decision.

People going to extremes for love, including a student who tunnels beneath the Berlin Wall, Edie Windsor topples the Defense of Marriage Act, and John Wojtowicz robs a bank to pay for his wife's gender reassignment surgery.

John F. Kennedy's doctor administers him meth for his back pain; Dr. John C. Lilly takes LSD while studying the intelligence of dolphins.

Journalist Maurine Dallas Watkins writes a play about Chicago's infamous cuddleesses' Row; Mata Hari goes from exotic dancer to double agent during World War I.

Colonial gossip columnist James Callender winds up dead; a Hollywood producer dies on a celebrity-filled yacht; Ken McElroy is cuddled after terrorizing a Missouri town.

Larry Walters pilots a balloon-suspended lawn chair; Phineas Gage survives an iron rod to the brain; and the Greenbrier Ghost's testimony is used in court.

Lead Belly records songs with John Lomax that change the face of music; John Lennon and Yoko Ono almost get deported; Sam Cooke writes "A Change Is Gonna Come".

Hedy Lamarr designs the first modern airplane wing, Eartha Kitt's activism provokes the ire of Lady Bird Johnson, and Alexis Pulaski's poodle becomes a huge star.

Forest service ranger Ed Pulaski saves 40 men from a forest fire; Ted Patrick rescues teenagers from the psychological grip of the Children of God cult.

Martha Mitchell leaks the Watergate scandal to the press before Deep Throat does; the Citizens' Commission to investigate the FBI stages an epic break-in.

Marina Raskova forms an all-women air force regiment to fight Nazis in World War II; smuggler James J. Andrews hijacks a Confederate train for the Union.

Navy officer Douglas Hegdahl outwits his captors when he's taken as a POW in North Vietnam; Florence Nightingale revolutionizes the field of nursing.

Mary Mallon spreads typhoid fever wherever she goes; Cleopatra's younger sister Arsinoe schemes her way in and out of power in Ancient Egypt.