After receiving word about events on Salusa Secundus, Valya brings Theodosia to the Imperial House to help manage the situation. Meanwhile, Desmond makes a confession to Emperor Corrino, Tula reluctantly enlists Lila for a vital mission, and distrust swirls around Keiran Atreides, the sword master for House Corrino.
Two Harkonnen sisters combat forces that threaten the future of humankind, and establish the fabled sect that will become known as the Bene Gesserit. Given extraordinary abilities by their mastery of the body and the mind, the Bene Gesserit expertly weave through the feudal politics and intrigue of The Imperium, pursuing plans of their own that will ultimately lead them to the enigmatic planet Arrakis, known to its inhabitants as Dune.