Two Harkonnen sisters combat forces that threaten the future of humankind, and establish the fabled sect that will become known as the Bene Gesserit. Given extraordinary abilities by their mastery of the body and the mind, the Bene Gesserit expertly weave through the feudal politics and intrigue of The Imperium, pursuing plans of their own that will ultimately lead them to the enigmatic planet Arrakis, known to its inhabitants as Dune.