Just out of the hospital and wanting to start his life over, Reid asks Amy out on a date. Amy talks a very reluctant Hannah into a double date with Amy's friend Nick, leaving Bright to deal with his pain and jealousy. Delia panics when her Bat Mitzvah falls on the same day as the birthday party of the most popular girl at school. Nina tries to deal with her confusing emotions over Andy and realizes she will have to make a decision when Jake asks her to move to Los Angeles with him. Harold points out to Rose that they were so caught up in the adoption procedure they've been taking each other for granted.
Dr. Andy Brown's seemingly perfect life was shattered when his wife, Julie, washuged in a tragic car accident. Prior to the accident, Andy was a world-famous neurosurgeon who often put his career before his family life. Now, Andy must single-handedly raise his two children, Ephram and Delia. In order to do so, Andy moved his family from New York City to the quiet, yet charming town of Everwood, Colorado.
In Everwood, Andy opened a free clinic, much to the dismay of most of the citizens. However, Edna Harper saw something in Andy that no one else saw and applied to be Andy's nurse and office manager. Andy was also well received by Irv, Edna's husband, and his new next-door neighbor, Nina Feeney. But along with the warm welcomes came the less than pleased individuals, including Dr. Harold Abbott, who forbade his wife Rose, and children, Amy and Bright to be around Andy or his children.
But regardless of such warnings, Amy quickly befriended Ephram, who instantly fell in love with her. Over the years, the two have formed a friendship, and for awhile, they even managed to be more than just friends. Ephram also formed an unlikely bond with Bright, and the two remain close friends, and recently have become roommates. Over time, Harold warmed up to Andy, and the two are now partners. However, despite the picturesque appearance of Everwood, the residents are faced with hardships and drama, including cancer, drug addiction, secret affairs, and tragic passings all while trying to live a quiet life in a small town.