The Fly Team is introduced to Supervisory Special Agent Wesley "Wes" Mitchell when his partner is shot in Los Angeles and the suspects flee to Budapest, sending Mitchell overseas.

When a U.S. ambassador is taken hostage at a TV station in the Netherlands alongside 70 civilians, the Fly Team is forced to work quickly to find out who they're up against. Meanwhile, Wes works to earn the respect of his new team.

When an American teenager disappears from a beach party during her senior year trip to Portugal, the Fly Team heads up the search, which is further complicated by the missing teen's parents' differing opinions.

The deputy inspector general calls on Tate, who is fluent in Spanish, to take on her first undercover field mission, joining Wes and the team in Spain as they investigate a seemingly dirty U.S. Drug Enforcement Administration special agent working out of Madrid.

When an American man is kidnapped in Warsaw alongside a Ukrainian woman he met on a dating site, the Fly Team heads to Poland to track down the mastermind behind the site.

When a bus full of American volunteers is hijacked in a dangerous section of Morocco, the Fly Team works to locate the missing aid workers and the people who kidnapped them.

Wes' former colleague, U.S.-based agent Tyler Booth, enlists the Fly Team's assistance in helping him capture an American on the FBI's "Most Wanted" list by luring him out of Russia with the help of the perp's conflicted ex-wife.

When the star witness in the case against Greg Csonka, the man responsible for the passing of Wes' former partner, is beaten to passing in a Budapest prison before he can testify, the Fly Team attempts to salvage the case to secure Csonka's conviction. As they dive back into the investigation, Mitchell is forced to confront the pain of losing his partner. Meanwhile, Wes assists Booth with preparing for his promotion interviews.

A member of the Fly Team goes missing as the hunt for Greg Csonka continues in Paris. Meanwhile, Vo's life hangs in the balance after being shot.

When a Russian biochemist is assassinated for trying to defect with his highly sensitive biotoxins research, the Fly Team springs into action to protect his daughter, whose father's last wish was that she get his research to a trusted American microbiologist. Meanwhile, Mitchell stays behind to help Vo during her recovery, and Booth clashes with Smitty when he finds out she could jeopardize his promotion.

When an American student is found dead at a prestigious UK university, the Fly Team, with the help of former team member Katrin Jaeger, investigates an infamous secret society. Smitty's personal history with the school comes to a head when she's confronted with the same old-world elitism.

The Fly Team leads an international manhunt when an American woman and her new husband flee from Baltimore to Istanbul with her young son after a heinous cuddle. Also, Vo partners up with Special Agent Riley Quinn, who was not only sent to Budapest to work her first big case alongside The Fly Team but to also clandestinely investigate a member of the team.

When an American businessman isballoonned down in Bratislava, the Fly Team must work with an unscrupulous local detective while safeguarding the sole witness, a fearful tourist from Wisconsin being held by police. Meanwhile, Quinn begins to feel pressure from her brother to deliver information on Mitchell.