Kate experiences the force of nature that is Tully when they meet as teens, at their first journalism jobs in 1982 and over a PTA crush in 2003.

A traumatic assault. A hidden romance. A signed consent form. Secrets both shared and unspoken test Kate and Tully's friendship over the years.

Sneaking out to a school dance, breaking a news story and enjoying a hip-shaking night on the town, Tully and Kate whirl through life together.

Tully and Kate weather health issues and romantic entanglements, from a college dalliance to a steamy encounter that leaves an ex hot under the collar.

Tully's lie threatens the pair's friendship. Kate feels stressed over huge life changes. A treasured gift leads to a gut-wrenching goodbye.

The BFFs catch the attention of a school bully. Kate attempts to move on. Tully faces choices that could change her life personally and professionally.

Tully's mom disappoints her again and again, and Kate's boozy night with her best friend and their coworkers causes awkwardness, accusations and hurt.

Vows are made and hearts broken as Kate navigates her long-strained relationship with her brother, and Tully grapples with compromise and commitment.

After one of Tully's birthdays ends in disaster, Kate becomes devoted to making her friend's big day special, even if her efforts don't always succeed.

Over holidays past and present, relationships shift - and truths are spoken - as Tully and Kate reshape their expectations for what the future holds.