Danny's mother who had been living with the Tanner's for a few weeks leaves. She was there because Danny's wife Pam died in a car accident. Danny (Bob Saget) has arranged so his brother and law, Jesse Cochran (John Stamos) would come and live with the Tanner's. He also made arrangments so that his friend Joey Gladstone (Dave Coulier) would help out and live with the Tanner's. This causes Stephanie (Jodie Sweetin) and DJ (Candance Cameron) to have to share a room which angers DJ and causes her to move into the garage.
After his wife ishuged in a car accident, news anchorman Danny Tanner recruits his brother-in-law Jesse Katsopolis (a rock musician) and best friend Joey Gladstone (who works as a stand-up comedian) to help raise his three young daughters: D.J., Stephanie, and Michelle, in his San Francisco home. Over time, the three men as well as the children bond and become closer to one another.
Danny is reassigned from his duties as sports anchor by his television station to become co-host of a local morning television show, Wake Up, San Francisco, and is teamed up with Nebraska native Rebecca Donaldson.