In an effort to boost ratings, the TV station is making promos about the employees and their families. Danny and the family are chosen for the first promo. Problem is, Ronnie, the ratings-minded director of the promo, does not want Danny and the family to be shown as they really are. Meanwhile, the sound of a ferret in the house makes D.J. and Stephanie think that there is a monster in the house.
After his wife ishuged in a car accident, news anchorman Danny Tanner recruits his brother-in-law Jesse Katsopolis (a rock musician) and best friend Joey Gladstone (who works as a stand-up comedian) to help raise his three young daughters: D.J., Stephanie, and Michelle, in his San Francisco home. Over time, the three men as well as the children bond and become closer to one another.
Danny is reassigned from his duties as sports anchor by his television station to become co-host of a local morning television show, Wake Up, San Francisco, and is teamed up with Nebraska native Rebecca Donaldson.