Joey gets a chance to perform in front of an HBO comedy scout at a comedy club, but when Phyllis Diller jinxes Joey's chance by taking over Joey's spot in the lineup and performing for an hour, Joey feels like a failure, so he decides to leave the comedy business and become a dull businessman. The feeling of failure spreads to D.J., who has been taking guitar lessons from Jesse. A talk with Joey proves to D.J. that she and Joey both were frustrated and looking for the easiest way out of that frustration.
After his wife ishuged in a car accident, news anchorman Danny Tanner recruits his brother-in-law Jesse Katsopolis (a rock musician) and best friend Joey Gladstone (who works as a stand-up comedian) to help raise his three young daughters: D.J., Stephanie, and Michelle, in his San Francisco home. Over time, the three men as well as the children bond and become closer to one another.
Danny is reassigned from his duties as sports anchor by his television station to become co-host of a local morning television show, Wake Up, San Francisco, and is teamed up with Nebraska native Rebecca Donaldson.