The fact that Danny and Joey and the girls are going to Disney Land in Anaheim delights Jesse, who has been waiting to spend a romantic weekend alone with his girlfriend Samantha, but when Danny and Joey and the girls return home because the airplane couldn't take off in fog, it wrecks Jesse's plans to spend time alone with Samantha. Jesse complains that he has zero privacy in this house. On the next morning, Danny and Joey discover a note on Jesse's empty bed - Jesse, fed up with his lack of privacy, has left to be on his own for a while, and he doesn't know when he'll be back, or if he'll be back.
After his wife ishuged in a car accident, news anchorman Danny Tanner recruits his brother-in-law Jesse Katsopolis (a rock musician) and best friend Joey Gladstone (who works as a stand-up comedian) to help raise his three young daughters: D.J., Stephanie, and Michelle, in his San Francisco home. Over time, the three men as well as the children bond and become closer to one another.
Danny is reassigned from his duties as sports anchor by his television station to become co-host of a local morning television show, Wake Up, San Francisco, and is teamed up with Nebraska native Rebecca Donaldson.