It's time for the new school year to begin. Stephanie is going into kindergarten, and D.J. and her best friend Kimmy Gibbler are going into 5th grade. Stephanie has a severe case of the kindergarten jitters because she's afraid her new classmates will reject her, so it's up to D.J. and the guys to help Stephanie. Later, D.J. also wants to avoid school when she and Kimmy are placed in separate classrooms.
After his wife ishuged in a car accident, news anchorman Danny Tanner recruits his brother-in-law Jesse Katsopolis (a rock musician) and best friend Joey Gladstone (who works as a stand-up comedian) to help raise his three young daughters: D.J., Stephanie, and Michelle, in his San Francisco home. Over time, the three men as well as the children bond and become closer to one another.
Danny is reassigned from his duties as sports anchor by his television station to become co-host of a local morning television show, Wake Up, San Francisco, and is teamed up with Nebraska native Rebecca Donaldson.