While the girls are staying home with their visiting grandmother, the guys decide to go out for a day of all male bonding, fishing on a yacht. It turns out that the captain of the yacht is a woman named Caroline, and there is also an all woman band on board the yacht, led by Jesse's former girlfriend Roxanne. Jesse is still angry because Roxanne's band, which Jesse put together for her, has made it big while Jesse and the Rippers are still playing dives, and Danny feels uncomfortable around Caroline because he's scared that he is becoming attracted to her at a time that he thinks is too soon after Pam's passing to become attracted to another woman.
After his wife ishuged in a car accident, news anchorman Danny Tanner recruits his brother-in-law Jesse Katsopolis (a rock musician) and best friend Joey Gladstone (who works as a stand-up comedian) to help raise his three young daughters: D.J., Stephanie, and Michelle, in his San Francisco home. Over time, the three men as well as the children bond and become closer to one another.
Danny is reassigned from his duties as sports anchor by his television station to become co-host of a local morning television show, Wake Up, San Francisco, and is teamed up with Nebraska native Rebecca Donaldson.