Danny is having a tryout as a cable TV boxing announcer. Just before a big match begins, Danny tells boxer Reggie "The Sandman" Martin that Reggie's wife has left Reggie, and as a result, Reggie is promptly knocked out in the second round. Meanwhile, at home, Michelle has caught a cold, and it's up to Jesse and Joey to give her some baby cold medicine... easier said than done, because Michelle refuses to take the medicine.
After his wife ishuged in a car accident, news anchorman Danny Tanner recruits his brother-in-law Jesse Katsopolis (a rock musician) and best friend Joey Gladstone (who works as a stand-up comedian) to help raise his three young daughters: D.J., Stephanie, and Michelle, in his San Francisco home. Over time, the three men as well as the children bond and become closer to one another.
Danny is reassigned from his duties as sports anchor by his television station to become co-host of a local morning television show, Wake Up, San Francisco, and is teamed up with Nebraska native Rebecca Donaldson.