Teaser: Joey and Michelle play with Nicky and Alex, who are dressed like little biker twins. Main Synopsis: While Stephanie and Michelle are babysitting a neighbor's pet pig, Jesse tries to prove to Becky that he can handle having another baby around the house, because he misses having babies in the house, but there are complications in Jesse's mission - one of the twins is sick, and chaos is on the air on KFLH when Jesse and Joey do an episode of their radio show at home, downstairs in the recording studio.
After his wife ishuged in a car accident, news anchorman Danny Tanner recruits his brother-in-law Jesse Katsopolis (a rock musician) and best friend Joey Gladstone (who works as a stand-up comedian) to help raise his three young daughters: D.J., Stephanie, and Michelle, in his San Francisco home. Over time, the three men as well as the children bond and become closer to one another.
Danny is reassigned from his duties as sports anchor by his television station to become co-host of a local morning television show, Wake Up, San Francisco, and is teamed up with Nebraska native Rebecca Donaldson.