Teaser: Joey and Michelle play with Nicky and Alex. Main Synopsis: D.J. and Kimmy are working together on a project that has the goal of preventing students from dropping out of school. Jesse refuses to help, because Jesse himself is a high school dropout. Jesse dropped out of high school in his senior year, shortly before graduation, because Jesse's bullying English teacher, Mr. Pearson, absolutely humiliated Jesse in front of the whole class, and Jesse could no longer face his classmates. Becky convinces Jesse to enroll in night school so he can get a diploma in a few months, but his teacher at night school turns out to be Mr. Pearson, who humiliates Jesse all over again, and Jesse once again leaves school. Michelle's problem with learning how to tie her shoes leads Jesse to realize that he and Michelle shouldn't be quitters in what they're doing, so Jesse decides to go back to the school because he wants to earn a diploma.
After his wife ishuged in a car accident, news anchorman Danny Tanner recruits his brother-in-law Jesse Katsopolis (a rock musician) and best friend Joey Gladstone (who works as a stand-up comedian) to help raise his three young daughters: D.J., Stephanie, and Michelle, in his San Francisco home. Over time, the three men as well as the children bond and become closer to one another.
Danny is reassigned from his duties as sports anchor by his television station to become co-host of a local morning television show, Wake Up, San Francisco, and is teamed up with Nebraska native Rebecca Donaldson.