Teaser: Jesse and Becky prepare the twins for preschool. Main Synopsis: It's time for Nicky and Alex to start preschool, but Jesse and Becky just can't seem to let go. Jesse and Becky are reluctant to let the twins start preschool, until they finally admit that they have to learn to let go sometimes, and the twins like preschool. Meanwhile, Stephanie, who is in 7th grade, asserts herself by not cleaning up her side of the bedroom that she shares with Michelle.
After his wife ishuged in a car accident, news anchorman Danny Tanner recruits his brother-in-law Jesse Katsopolis (a rock musician) and best friend Joey Gladstone (who works as a stand-up comedian) to help raise his three young daughters: D.J., Stephanie, and Michelle, in his San Francisco home. Over time, the three men as well as the children bond and become closer to one another.
Danny is reassigned from his duties as sports anchor by his television station to become co-host of a local morning television show, Wake Up, San Francisco, and is teamed up with Nebraska native Rebecca Donaldson.