The battle between Al and Number 66 is interrupted by the appearance of Scar. As the three square off, Number 66 triggers an explosion that causes yet more trouble for everyone involved. Meanwhile, Ed and Number 48 have reached the deepest parts of the Fifth Laboratory. Now, Ed faces a bigger threat as his morality is challenged by someone from his past; will he give in to the temptation of the power he has been seeking, or will he hold true to his beliefs?
'Humankind cannot gain anything without first giving something in return. To obtain, something of equal value must be lost. That is Alchemy's first law of Equivalent Exchange. In those days, we really believed that to be the world's one, and only, truth'.
-Alphonse Elric
Edward and Alphonse Elric are two brothers gifted with the ability of alchemy, the science of taking one thing and changing it into another. However, alchemy works on the theory of Equivalent Exchange - for something to be created, something else of equal value must be sacrificed. When their mother dies, Edward decides to do the unthinkable - bringing her back to life by breaking one of Alchemy's biggest taboos and performing Human Alchemy. Thinking they have nothing more to lose, he and Alphonse make their attempt - but something goes horribly wrong. In the process, Alphonse loses his body and Edward loses his leg. Ed manages to save Al by attaching his spirit to a suit of armor, but at the cost of his arm and leg.