A car crashes through the ER injuring several hospital members. Former Port Charles resident Jagger Cates returns to town, as does former Night Shift janitor Toussaint; a batch of new interns makes the rounds on the Night Shift.

Robin frantically searches for a donor for a sick child and also argues with Jagger over Stone; Claire wards off the advances of a patient; Leo and Kyle try to resolve their issues.

Robin's father Robert unexpectedly shows up in the ER as a patient; Toussaint and Epiphany explore their relationship; Claire and Kyle clash as roommates; Leo and Saira fight their attraction to each other.

A French woman attacks Patrick; Robin gives her dad troubling news; Saira evalutes Jagger's son; Toussaint and Epiphany go on their first date; and Kyle teaches sex-ed to some unlikely students.

Robin clashes with her stubborn father, Robert, over his medical treatment; Kyle sees his brother, Leo, in a new light after an encounter with a patient's homophobic family; Jagger reluctantly allows Saira to treat Stone for autism; and a "inactive person" shocks Toussaint and Claire.

A quarantined couple makes Patrick view Robin's HIV status in a new light; a jealous Leo tries to come between Jagger and Saira; Robert's health suffers again; Claire tries to improve Kyle's love life, unbeknownst to him.

Robin must make a life-or-passing decision regarding her father, Robert, who undergoes surgery; Jagger finds support in a group for parents with autistic children; Leo and Saira put their differences aside and work together to help a patient; Claire has a run-in with an old classmate.

The FBI assigns Jagger to investigate an organ-selling ring at GH; cancer-patient Robert has a most difficult time; relationship troubles plague Leo and Saira and Toussaint and Epiphany.

Jagger's son, Stone, is brought into GH after a seizure; Patrick feels left on the sidelines as Robin's occupied with her ailing dad and Jagger's emergency; Claire and Leo are conflicted over developments in their personal life; Kyle helps Saira start a breast milk bank for GH.

Mrs. Julian, Leo and Kyle's mother, drops by unexpectedly to visit her two sons; Kyle develops an attraction to a new patient; Claire divulges a secret; Robert appreciates his daughter, Robin, and begins to understand her; Patrick is left in a no-win situation.

Racist patients cause trouble for the doctors and nurses; Anna, Robin's mother, stops by GH when Robert has emergency surgery.

Monica stops by General Hospital; Anna and Robert discuss their past; The hospital is in danger thanks to Patrick; Eric and Kyle's relationship grows.

In the first part of the season finale, Robert lies in a coma while his old friends Luke, Sean and Tiffany pay him a visit; Jagger is sued for custody over Stone; Toussaint gets a surprise in the mail; Claire has an important career decision to make; there's a major development in Kyle and Eric's relationship.

The doctors must save Saira after the explosion; Robert and Anna take a major step; Claire and Kyle become friends again; Patrick and Jagger have to stop a bomb from going off.