When a terminally ill patient claims that she recognises Zosia as her own daughter, Zosia embarks on a mission to save her life whilst trying to figure out their past connection. As the patient's condition rapidly deteriorates, Zosia's behaviour becomes worryingly out of control and Guy is pushed to take extreme action. Mo's elated when Jessie asks her to perform a duet with him at the Christmas party, setting her on a path to finally follow her heart and admit that she's fallen in love with him. However, this romantic notion is quashed when she spots Jesse kissing her sister Adele. Serena learns that Raf and Harry still don't know which of them fathered Amy's baby and she decides to lend a hand in getting the ball rolling. Amy confides in Serena that she wants to go ahead with the paternity test and Serena fast-tracks the results.
This series is a spin-off from the long running BBC medical drama Casualty. Set in the same hospital as its sister series, this show follows the everyday lives, professional and personal, of the doctors, nurses and patients who find themselves, for various reasons, in the wards of Holby City General Hospital