Frankie returns to Holby, keen to take Isla back. Essie is not convinced she is truly ready for the demands of parenthood, and tries to persuade her to leave her daughter behind. A top neurosurgeon has a radical idea for how to treat Ric's tumour, but Serena is not convinced by the plan. Ric is left to consider both their positions, and decide what he wants to do. Jac returns from holiday, and asserts her authority over an overworked Kian.

Holby City Season 21 Episodes...

• s21e01 - Everything Old Is New Again
• s21e02 - China Crisis
• s21e03 - The Burden of Proof
• s21e04 - A Daring Adventure or Nothing At All
• s21e05 - Mad as Hell
• s21e06 - Force Majeure
• s21e07 - Good Side
• s21e08 - Never Say Never
• s21e09 - Guts
• s21e10 - Powerless
• s21e11 - A Simple Lie, Part One
• s21e12 - A Simple Lie, Part Two
• s21e13 - Running
• s21e14 - Ask No Questions
• s21e15 - The Family Way
• s21e16 - North and South
• s21e17 - Pleased to Meet You
• s21e18 - Vinegar and Honey
• s21e19 - Ex Marks The Spot
• s21e20 - The Wrong Horse
• s21e21 - Unredeemed
• s21e22 - Bloodline
• s21e23 - In the Right Place
• s21e24 - Over My Dead Body
• s21e25 - Pigeon
• s21e26 - Kiss Kiss
• s21e27 - Flying Solo
• s21e28 - Reckless
• s21e29 - Honeymoon
• s21e30 - Don't Leave Me
• s21e31 - Things My Mother Told Me
• s21e32 - When Worlds Collide
• s21e33 - Work Life Balance
• s21e34 - Where Does It Hurt?
• s21e35 - Babysitters and Bystanders
• s21e36 - The Perfect Storm
• s21e37 - Gods and Monsters
• s21e38 - Circle of Life
• s21e39 - Retreat
• s21e40 - Divine Justice
• s21e41 - This Be The Verse
• s21e42 - Hope Is a Powerful Drug
• s21e43 - Promise
• s21e44 - Hubble Bubble
• s21e45 - Remember, Remember
• s21e46 - Sandra's Choice
• s21e47 - We Are All the Stars
• s21e48 - Blurring the Lines
• s21e49 - Bell Jar
• s21e50 - Kintsugi
• s21e51 - Lemons
• s21e52 - Be True, Be Brave, Be Kind
• s21e53 - Mothers and Their Daughters

Holby City Show Summary

This series is a spin-off from the long running BBC medical drama Casualty. Set in the same hospital as its sister series, this show follows the everyday lives, professional and personal, of the doctors, nurses and patients who find themselves, for various reasons, in the wards of Holby City General Hospital