A dying child needs a risky operation in order to survive. However, Sam does not have faith in Meyer's ability to carry out the procedure as he performed it before a little girl died. She voices her concerns to the child's parents who then discharge their son from the hospital. The boy returns in a critical condition. Meanwhile, Janice is thrown into turmoil when her unborn baby is in danger. And Chrissie is forced to care for Owen's runaway child.
This series is a spin-off from the long running BBC medical drama Casualty. Set in the same hospital as its sister series, this show follows the everyday lives, professional and personal, of the doctors, nurses and patients who find themselves, for various reasons, in the wards of Holby City General Hospital