Mark and Tricia's anticipation of their honeymoon is ruined when a furious Chrissie discovers her mother's cancer has returned and demands to know why she wasn't told. Sam gets emotionally involved in the case of a teenage girl with hepatitis C whose parents seem to know little about her medical history, and Matt struggles to fight his growing attraction to patient Nikki
This series is a spin-off from the long running BBC medical drama Casualty. Set in the same hospital as its sister series, this show follows the everyday lives, professional and personal, of the doctors, nurses and patients who find themselves, for various reasons, in the wards of Holby City General Hospital