When Rogelio tells Jane that the network wants her to write the script for their telenovela, at first she is excited, but begins to struggle balancing her time between that and her novel. Rafael is furious with Jane after she makes a medical appointment that he doesn't agree with behind his back. Meanwhile, Petra tries to be positive about their relationship when JR lands a job interview out of state.
Set in Miami, the series details the surprising and unforeseen events that take place in the life of Jane Villanueva, a hard-working, religious young Latina woman whose family tradition and a vow to save her virginity until her marriage to a detective is shattered when a doctor accidentally artificially inseminates her by mistake during a checkup. And to make matters worse, the biological donor is a married man, a former playboy and cancer survivor who is not only the new owner of the hotel where Jane works, but was also her former teenage crush.