After Rafael witnesses Mateo's behavior at school, he wants to take a different approach to his treatment. Rogelio is paranoid that River is plotting her revenge against him. Jane convinces Petra to go on a single ladies' night out after she learns that Rafael is dating.
Set in Miami, the series details the surprising and unforeseen events that take place in the life of Jane Villanueva, a hard-working, religious young Latina woman whose family tradition and a vow to save her virginity until her marriage to a detective is shattered when a doctor accidentally artificially inseminates her by mistake during a checkup. And to make matters worse, the biological donor is a married man, a former playboy and cancer survivor who is not only the new owner of the hotel where Jane works, but was also her former teenage crush.