When Lina comes to town, Jane is excited to see her until Lina asks her for a favor. Rafael begins to work with Petra again but old tensions create new problems between them. Rogelio creates a plan to pressure the network to pick-up his pilot. Meanwhile, Jane and Rafael have been looking for a solution to one of their problems and think Alba just might be the answer.
Set in Miami, the series details the surprising and unforeseen events that take place in the life of Jane Villanueva, a hard-working, religious young Latina woman whose family tradition and a vow to save her virginity until her marriage to a detective is shattered when a doctor accidentally artificially inseminates her by mistake during a checkup. And to make matters worse, the biological donor is a married man, a former playboy and cancer survivor who is not only the new owner of the hotel where Jane works, but was also her former teenage crush.