Jane is trying to go with the flow, so when Michael makes a suggestion to Jane which takes her out of her comfort zone, Jane decides to go for it. Jane struggles to adjust while Michael slides back into his old life. Meanwhile, Jane struggles with her feelings for Rafael.
Set in Miami, the series details the surprising and unforeseen events that take place in the life of Jane Villanueva, a hard-working, religious young Latina woman whose family tradition and a vow to save her virginity until her marriage to a detective is shattered when a doctor accidentally artificially inseminates her by mistake during a checkup. And to make matters worse, the biological donor is a married man, a former playboy and cancer survivor who is not only the new owner of the hotel where Jane works, but was also her former teenage crush.