God instructs Joan to help out with the a chaotic Girardi household; Adam has his first art show; Will and Toni witness a carjacking. Will and Toni, while making an arrest, get stuck in an elevator with a pregnant woman who is about to give birth; Kevin believes he might be recovering some sensation in his stomach area and gets an EMG (a nerve conduction) test done.
A drama about a typical family, the Girardis, facing atypical situations - not the least of which is their teenage daughter Joan's sudden, unexpected conversations with God in such random forms as a cute boy, Goth kid, little girl or the school lunch lady. Joan (Amber Tamblyn) must endeavour to balance the natural and supernatural elements of her life, often with little success. This is not the only major problem the family must face as her elder brother Kevin (Jason Ritter) was paralysed from the waist down in a car accident in 2002. As a result, her younger brother Luke (Michael Welch) often feels that his needs are being ignored.