When the hospitalized Joan is diagnosed with Lyme disease, she begins to question if she's been seeing God or merely experiencing the hallucinations that can be symptomatic of her condition...
Upon hearing that Joan may have been suffering from the symptoms of Lyme Disease for months, a somewhat relieved Will and Helen believe this news may explain Joan's mood swings and atypical behavior, while a concerned Adam wonders if Joan will be different upon her recovery. Meanwhile, the hospitalized Joan experiences a crisis of faith -- and considers revealing to someone close to her that she's been talking to God. In separate circumstances, Helen and Will begin to rethink their belief systems after, respectively, experiencing spiritual dreams and miraculous events.
A drama about a typical family, the Girardis, facing atypical situations - not the least of which is their teenage daughter Joan's sudden, unexpected conversations with God in such random forms as a cute boy, Goth kid, little girl or the school lunch lady. Joan (Amber Tamblyn) must endeavour to balance the natural and supernatural elements of her life, often with little success. This is not the only major problem the family must face as her elder brother Kevin (Jason Ritter) was paralysed from the waist down in a car accident in 2002. As a result, her younger brother Luke (Michael Welch) often feels that his needs are being ignored.