A toxic Black Rain storm causes John and Pawter to take shelter in the Royale overrun with a gang of dangerous criminals. Dutch and D'avin are stuck on Lucy as they come perilously close to the eye of the storm.
Killjoys follows a trio of hard-living bounty hunters - Dutch, John, and D'avin - taking on interplanetary missions, chasing and capturing deadly criminals throughout a distant system named the Quad. They have sworn amongst themselves to remain neutral during a bloody, multi-planetary class war that threatens to destroy the Quad. However, their own pasts and the events around them begin to draw them in deeper to this dangerous vortex of war.