It's a Fab Five-way throwdown as "Queer Eye" guys Karamo Brown and Jonathan Van Ness battle costars Antoni Porowski, Tan France and Bobby Berk for the championship belt.

Singer, songwriter and bona fide legend Mariah Carey graces the stage as actor Darren Criss and rapper-producer Jermaine Dupri battle it out to the tune of her iconic hits.

Serena Williams guest stars in a husband vs. wife battle as tennis legend Andy Roddick takes on actress and supermodel Brooklyn Decker.

Special guest John Legend joins the crew as singer/songwriter Andy Grammer takes on "Riverdale's" Vanessa Morgan, and they battle it out for the LSB championship belt.

Husband Boris Kodjoe (Station 19) and wife Nicole Ari Parker (Empire) battle on the LSB stage as they square off for household bragging rights and the LSB championship bel.

It's a "Superstore" super battle when Ben Feldman battles co-star Lauren Ash for the LSB Championship belt.

"Black-ish" actor Marcus Scribner takes on "God Friended Me" actor Brandon Micheal Hall.

Fresh off "Sesame Street", Big Bird squares off against actor Jason Schwartzman.

Actor Nico Tortorella ("Younger") squares off against co-star Molly Bernard.

American Ninja Warrior hosts Matt Iseman and Akbar Gbaja-Biamila go head to head and battle it out in the ultimate arena, the Lip Sync Battle stage.

Actor-rapper Pooch Hall takes on his "Ray Donovan" on-screen brother, Dash Mihok.

Prince Royce and singer-internet sensation Lele Pons heat things up on the stage as they compete for the coveted championship belt.

It's a battle for the ages as Serayah ("Empire") takes on Rotimi ("Power").