George has to navigate political correctness in order to convince a transgender actress to co-star in "Valleys". Meanwhile, Manolo has problems with bullies at school and Maronzio starts a podcast.
Lopez revolves around America's most successful Hispanic American comedian, explores how George struggles between his two worlds and crises - often of his own making. Too rich to go back to his working class, Latino roots, and too "brown" to feel comfortable in his affluent celebrity life, being George Lopez comes with many problems.