During a stand up routine, Louie discusses serious topics such as child abuse and abduction. In the first segment, Louie goes to a new dentist who's afraid of dentists himself and specializes in calming patients fears. Louie is anesthetized and provided with middle eastern music. While under, he dreams about speaking with Osama Bin Laden and a group of terrorists. The group discuss ethics and the 9/11 attacks. Louie then dreams that the dentist is putting a banana in his mouth. When he wakes up he finds the dentist frantically zipping his pants, implying that Louie was orally raped. While performing stand up, Louie discusses the intricacies of male sexuality. In a second segment, he attempts to court a black woman named Tarese who works at the local grocery store. After buying groceries, Louie buys the woman flowers (from the same store), checks out at her register, and then gives the flowers to her. Tarese calls the manager to complain and the manager reimburses Louie for the flowers. Louie is waiting for the woman when she gets off of work, and walks home with her. Although Tarese is openly not interested, Louie walks with her to her apartment, where he is turned down. He then meets her sister as she is leaving the apartment complex. The next scene shows the two performing coitus. In a closing stand up segment, Louie professes his love for Jewish women.
Season 1 Episode 10 of Louie resulted in a 0.00 rating in the 18-49 demographic.
Louie is a comedy filtered through the observational humor of Louis C.K. Each episode puts a spotlight on Louis' hectic life as a successful stand-up comedian and newly single father raising his two daughters. The single-camera comedy is a mix of Louis C.K'.s stand-up comedy and scripted short films.