Louie waits at Grand Central Station to pick up his sister and niece for a visit. However, his sister surprises him by dumping the niece Amy on him and running off to catch a train to Philadelphia. Louie and Amy spend the night in New York together, visiting an indie rock club at her request, after which she asks to see Louie perform. After seeing her enamored with Godfrey's set, Louie attempts, unsuccessfully, to impress his niece by doing crowd work. After the set, Louie is surprised to see Godfrey spark up a lively conversation with the usually sullen teen. When they arrive back at the apartment, Louie receives a call from a Philadelphia hospital informing him that Amy's mother was found "acting irrationally" in a public fountain and that she is being held under observation. With Amy's father out of the picture, Louie volunteers to keep Amy until his sister is released.
Season 2 Episode 12 of Louie resulted in a 0.00 rating in the 18-49 demographic.
Louie is a comedy filtered through the observational humor of Louis C.K. Each episode puts a spotlight on Louis' hectic life as a successful stand-up comedian and newly single father raising his two daughters. The single-camera comedy is a mix of Louis C.K'.s stand-up comedy and scripted short films.