Colonel Flagg blows into camp trying to obtain penicillin to barter for information. But Flagg comes down with appendicitis, and the only penicillin he gets is in the keister.
The 4077th Mobile Army Surgical Hospital is stuck in the middle of the Korean war. With little help from the circumstances they find themselves in, they are forced to make their own fun. Fond of practical jokes and revenge, the doctors, nurses, administrators, and soldiers often find ways of making wartime life bearable.