Charles returns to the 4077th after a trip to Tokyo with an uncharacteristic hangover and the uneasy feeling of a romantic entanglement. Meanwhile, the hospital struggles to find a cure for an outbreak of deadly hemorrhagic fever.
The 4077th Mobile Army Surgical Hospital is stuck in the middle of the Korean war. With little help from the circumstances they find themselves in, they are forced to make their own fun. Fond of practical jokes and revenge, the doctors, nurses, administrators, and soldiers often find ways of making wartime life bearable.