Spider-Man and Miles Morales discover Doc Ock, whose mind has been hiding inside the metal body of The Living Brain, has been behind the mysterious bounty for Spider-Man's head.
An insecure but courageous and intelligent teen named Peter Parker, a new student of Horizon High, is bitten by a radioactive spider and given powers. He becomes a hero named Spider-Man after the passing of his uncle and he must adapt to this new way of life.