Spider-Man has to take down the slick new villain Slyde, who is stealing various chemicals from around the city in an effort to create a deadly virus that could wipe out New York.
An insecure but courageous and intelligent teen named Peter Parker, a new student of Horizon High, is bitten by a radioactive spider and given powers. He becomes a hero named Spider-Man after the passing of his uncle and he must adapt to this new way of life.