Langham observes Masters and Johnson exiting a hotel room and shares his suspicions with DePaul, who is forced to make plans for her work without Virginia's involvement. Meanwhile, Betty attempts to conceal her infertility from Gene; and Masters tries to bring Johnson aboard as his assistant only to be thwarted by the head of the hospital, who takes a prurient interest in Masters' study.
William Masters and Virginia Johnson were the real-life pioneers of the science of human sexuality. The series chronicles the unusual lives, romance and pop culture trajectory of Masters and Johnson.
Their research touched off the sexual revolution and took them from a mid-western teaching hospital in St. Louis to the cover of Time magazine and nearly a dozen appearances on Johnny Carson's couch.