At the forefront of the Sexual Revolution, Masters and Johnson are about to publish their study, finally removing the shroud from the work that's consumed them for the past decade. As they face the press for the first time, they flashback to a summer vacation of the year prior, where Virginia is faced with parenting struggles, Bill is finishing work on their book, and Libby is pulling herself out from beneath a deep depression.

The shockwaves surrounding the events of Masters and Johnson's first press conference begin to reverberate around their universe as the book nears its release date. Bill takes on a powerful, high profile fertility patient with the help of a new doctor in the practice, while Virginia and Libby come to terms with Bill's role in Gini's life.

Masters and Johnson's book is released and, while reviews are positive, the public's response causes unease around the office. The new spotlight on her mother starts to affect Tessa at school, while Libby does her best to maintain a social life outside of her friendship with Virginia. Meanwhile, Masters and Johnson look to old and new places to capitalize on their burgeoning fame.

Masters consults unexpected advice in convincing Johnson to rededicate herself to the study and to him. A familiar face returns to the clinic for help. Meanwhile, Virginia is distracted by news of Henry and fails to notice Tessa trying to make sense of her home life. Libby confronts the truths of hers as she helps Paul and Joy pick up the pieces of their shattered lives.

Virginia's parents arrive unannounced. Meanwhile, Libby and Masters discover Johnny has been bullied and look to fix it in their own ways. Plus, Johnson finds unexpected excitement in the scent study while Masters, looking to overcome his embarrassing departure from the university, takes on a promising fertility patient that could land him and Johnson back in good graces.

As a result of their spreading celebrity, Masters and Johnson take on a famous couple looking to reinvigorate their sex life. Meanwhile, Tessa learns what childhood with Edna Eshelman must have been like for Virginia. Plus, Masters attempts to connect with Johnny, but misses the mark entirely, and Libby furthers her involvement in Joy's life - with consequences that extend to Paul.

Masters and Johnson are interviewed by 'Newsweek' as they take on an exotic new patient. Meanwhile, Dan Logan tries to read Virginia. Plus, Libby and Paul deal with the fallout of exposed truths.

As Johnson jets away to Las Vegas with Dan Logan, Masters uses her absence to begin his surrogacy program. Meanwhile, Libby comes to terms with her current and past relationships. And Barton considers starting one of his own.

Libby tries to mask her feelings by setting Paul up with a friend. Meanwhile, Masters continues his surrogacy program, now under the critical eye of Johnson. And Lester volunteers as their first male surrogate.

Johnson objects to Masters' program following missteps in the protocol.

Masters, Johnson, Logan and his wife gather in New York for a dinner in which agendas collide, truths are exposed and no relationship emerges unscathed. Back home, Libby faces an accusation that threatens her family's foundation.

On the heels of their disastrous dinner in New York, Masters and Johnson return to find their life's work in jeopardy while under the scrutiny of the press and their publisher in preparation for their new book.