After Alison Bannister is diagnosed with a brain tumour, Monroe has to help her deal with a frightening decision.

Monroe finds it hard to deal with the fact that his wife has left him and he throws himself into work even more. He attempts to find the courage to admit to his son the truth about why his marriage finished. Monroe and Jenny have to deal with a double shooting after a boy accidentally shoots his 12-year-old brother and then turns theballoon on himself.

The family home is up for sale and Nick refuses to answer his calls as Monroe continues throws himself into his work. After a former soldier is admitted to the hospital suffering with blood clot in his brain, Monroe decides to avoid surgery. He is pressurised though to change his mind.

Monroe finds his personal life going further into chaos as he learns that a civilised divorce is much harder than he thought it would be. At work he attempts to convince Brendan Cormack to go ahead with an operation that will help control the epilepsy he suffers with. Brendan though thinks that God is speaking to him during his seizures and is reluctant to give up talking to him. Bremner's suspiciously good mood leaves Witney and Mullery feeling unnerved. Bremner is furious though when Monroe lets her know about the secret relationship she is in.

After Sally Fortune collapses with an aneurysm in her brain, Monroe has to operate on a work colleague. His relationship with Bremner ends up reaching crisis point after she involves herself in Sally's treatment. Witney has to deal with a patient who refuses to have her surgery cancelled. Monroe attempts to help Anna create a new life.

Monroe finally ends up confronting the painful truth about his past after a busy night shift at the hospital ends up taking a darker turn when a 13-year-old girl is admitted following being involved in a road accident. Monre knows that there is little hope that the girl will survive. Shepherd is getting over his break-up with Bremner, but finds it impossible to keep out of her way at the hospital.