To get strong enough to pass an obstacle course, Dr. Cockroach tweaks his 50/50 man/roach genetic makeup so he'll be 40 percent man and 60 percent roach. Unfortunately, his roach side keeps increasing at the cost of his human side and its intellect, forcing his teammates to find a way to reverse the process.
Inspired by DreamWorks Animation's 2009 blockbuster feature film, this new series follows the further adventures of the beloved monsters- B.O.B., the gelatinous blob without a brain; Link, the prehistoric fish-man; Dr. Cockroach, the half-man/half-insect mad scientist; and Susan (aka Ginormica), the incredible growing woman-as they learn to adapt to a new world filled with bizarre aliens.