Mick arrives at Josef's office building, which is on fire. Nothing is left intact. No survivors. Someone who knew Josef was a vampire attacked him with one of the two known ways tohug a vampire. Mick and Tom, Josef's head of security, launch in investigation into the attack. Beth does her own investigating and interviews several people from Josef's past, none of whom have anything nice to say. The twin investigations lead Mick and Beth to New York, and yet another surprise from Josef's past.
Moonlight follows Mick St. John, an immortal vampire and private investigator and his struggle to exist after he was bitten 60 years ago by his vampire bride on their wedding night. It also follows his internal torment as he falls in love with one he should not, one who is mortal named Beth, a news reporter, as well as his dealings with the woman who made him a vampire, his sire Coraline.