The team investigates the passing of a Naval microbiologist whose hobby as a 'myth buster' resulted in his passing at the hands of a legendary bayou creature. Khoury conducts an investigation into previous actions of Deputy Director Van Cleef, who recently demoted her for misguided allegations that she exhibited poor judgment.
The local NCIS field office investigates criminal cases affecting military personnel in the Big Easy, a city known for its music, entertainment and decadence. Leading the team is Special Agent Dwayne Pride, aka 'King', a native of NOLA who is driven by his need to do what is right. Working with Pride is Special Agent Christopher LaSalle, who plays hard but works harder; and Special Agent Meredith 'Merri' Brody, a charismatic and tough interrogator who transferred from the Great Lakes office in search of a fresh start. Supporting them is coroner Dr. Loretta Wade, who is as eccentric as she is smart. This colorful city that harbors a dark side is a magnet for service personnel on leave, and when over-indulgence is followed by trouble, Pride's team is at its best.