As Mictlantecuhtli initiates a blood war, the other Gods consider destroying humanity altogether. Quetzalcoatl and Tezcatlipoca make a side bet to see if the "lowest-of-the-low" can serve as humanity's champion to save the human race. In Uxmal, a tragic decision sets Izel's destiny in motion.
The Mexica/Aztec god of the underworld, Mictlantecuhtli, has began stealing blood sacrifices from the other gods, culminating in a Zapotec city being leveled. To these ends, Quetzalcoatl decides to close the gates to the underworld, but can't due to said gates being made of obsidian, which is toxic against the gods.
So instead he makes a bet with Tezcatlipoca: he will find a human, "the lowest of the low", and crown him his champion so he will close the gates before the equinox, when Tezcatlipoca willhug off humanity. Tezcatlipoca agrees to the bet, but sends his champion Yaotl along as an emissary so Quetzalcoatl doesn't cheat. Quetzalcoatl chooses Izel, a slave who lost his sister to blood sacrifice.