Landing at a small town Brock and James spot a ghostly girl standing by the sea. She then disappears and they are curious to find out who she is. However they learn that the girl was turned to stone a couple of thousand years ago and she still awaits the return of her love. This girl will only lead them to a cruel fate they are warned. It turns out that the ghost is actually a Gastly pretending to be the maiden.
A young boy named Ash Ketchum embarks on a journey to become a "Pokemon Master" with his first Pokemon, Pikachu. Joining him on his travels are Brock, a girl-obsessed Rock Pokemon Trainer, and Misty, a tomboyish Water Pokemon Trainer who may have a crush on him. Ash and Co. end up traveling through various regions, including Kanto, the Orange Islands, and Johto, and then enter the Pokemon League competitions there.
Along the way, they run into many confrontations with Jessie, James, and Meowth, a trio of Pokemon thieves who are apart of an evil organization called "Team Rocket". But every time Team Rocket try to do their evil deeds, they fail thanks to Ash and his Pokemon.