Ash and friends arrive in Cerulean City and Ash must battle Misty to recieve the Cascade badge. Later on, their battle is interupted by Team Rocket who attempts to snatch all the Pokémon in the Gym with a giant vacum! Then Pikachu uses his thunderbolt on Team Rocket and they are blasting off again.
A young boy named Ash Ketchum embarks on a journey to become a "Pokemon Master" with his first Pokemon, Pikachu. Joining him on his travels are Brock, a girl-obsessed Rock Pokemon Trainer, and Misty, a tomboyish Water Pokemon Trainer who may have a crush on him. Ash and Co. end up traveling through various regions, including Kanto, the Orange Islands, and Johto, and then enter the Pokemon League competitions there.
Along the way, they run into many confrontations with Jessie, James, and Meowth, a trio of Pokemon thieves who are apart of an evil organization called "Team Rocket". But every time Team Rocket try to do their evil deeds, they fail thanks to Ash and his Pokemon.